The reigning Defensive Player of the Year has a new home, but injury is going to take a toll on his chances of repeating. Myles Garrett won the AP NFL DPOY award unanimously in 2025, receiving all 50 first-place votes after breaking the single-season sack record with 23 sacks. That was the second DPOY win of his career, and he trails only Lawrence Taylor, J.J. Watt and Aaron Donald for the most DPOY awards in NFL history, with each of those names nabbing the award three times. Both Watt and Donald won three in the span of four years, and while Garrett opened the year favored to do just that, a knee injury has sidelined him for at least the next four weeks and dropped his odds to +5000. Let’s take a look at the odds to win the 2026 NFL Defensive Player of the Year at FanDuel Sportsbook as of Sept. 29. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. What To Know: Anderson is the star of a vaunted Houston defense, one that was best in the league last year. Through three games in 2026, Anderson has recorded 18 total tackles (10 solo), four sacks and six tackles for loss. Since Myles Garrett’s injury, he’s been the new favorite in this spot. What To Know: Hutchinson is finding his way to the opposing quarterback … often. He has four sacks and seven QB hits through three weeks. He also has three tackles for loss. Still, the Lions have given up 85 total points so far this season. What To Know: So far this season, Greg Rosseau has tallied 12 tackles, eight tackles for loss, six sacks and has forced three fumbles. In the Bills’ Week 3, 24-16 win over the Chargers, he had five solo tackles and came up with two sacks. What To Know: Watt opened the season with two sacks, four tackles, three tackles for loss and two QB hits in the Steelers’ win over the Falcons. He added 1.5 sacks, another tackle for loss and two more QB hits in Week 2. That start moved the 2021 Defensive Player of the Year’s odds to +550 from +1100. But after a somewhat quiet Week 3 where he assisted on one tackle, his odds moved back to +1100. What To Know: What a tumultuous offseason for Crosby, who thought he was a Raven until he wasn’t. In the Raiders’ Week 1 win over Miami, he had 1.5 sacks, three QB hits and a tackle for loss. After two weeks, Crosby led his Raiders’ defense that ranks second in the NFL in pressure rate at 44.1% and was a big part of the upset win over the Chargers. In the team’s Week 3 win over New Orleans, Crosby recorded two tackles (one solo, one assisted). Click Here for more
